CRC 815

“Redox-Regulation: generatorsystems and functional consequences”


Collaborative Research Center 815

Since January 2009 the DFG is funding the Collaborative Research Center 815 “Redox-Regulation” at the Goethe-University Frankfurt. After the successful reapplication we are within our second funding period, starting January 2013.

In past, redox signaling has often been studied under pathological conditions like oxidative stress. It is a new concept to recognize redox-regulation as a universal element of cellular signaling. It can be seen as a fundamental control mechanism like phosphorylation/ dephosphorylation in regulating and coordinating cellular functions.

Within the first funding period we focused on activation of generating systems, the formation of redox active metabolites, and characterization of redox modulated target structures.

In the second funding period we aim at using the accumulated knowledge of generating systems and modified target structures to explore functional consequences.