A good example for our approaches in Clinical Neuroscience is illustrated by ongoing scientific work in the psychiatric and neurological departments: research in psychiatry focuses on the neurobiology underlying the development of mental disorders (especially autism, ADHD, anxiety and mood disorders) over the early life span applying a variety of methods from genomics, animal and cell models to multimodal imaging and behavioral methods like eye tracking. By disentangling the obvious heterogeneity of psychiatric disorders based on objective measures, this research is geared towards establishing precision medicine and stratified therapy approaches. Phase-IIa and Phase-III clinical studies are accordingly coordinated on a regular basis.
Clinical neurology has a longstanding tradition in translational neurovascular, neuro-oncological and neuro-pharmacological research and epileptology. Also here research approaches bridge the gap between all subfields of neuroscience in interdisciplinary teams. Often, this work requires access to large samples of patients, so that clinical neuroscience research groups are very active (including coordination) in national and international research consortia funded by the EU, BMBF and DFG.
Bringing together neuroscientific research from all the different levels there is the Focus Program Translational Neuroscience (FTN) in Mainz. Here, about 80 research groups (https://www.ftn.uni-mainz.de/organisation-und-mitglieder/liste-der-mitglieder/) are active in many departments ranging from basic research to clinical patient work The FTN (https://www.blogs.uni-mainz.de/ftn-eng/) serves as a hub for neuroscience research in Mainz and aims to support neuroscience research by offering services in the collaborative network of rmn2. The goal of the basic researchers and clinicians working in the FTN is to clarify physiological and pathophysiological measures for processes of neural adjustment and homeostasis of the nervous system, as well as translating the results into clinical activities. FTN is aiming at contributing to the clinical implementation of the almost exponentially growing increase of knowledge in the fields of molecular and cellular neurosciences.
The Leibniz Institute for Resilience Research (LIR) (https://lir-mainz.de/home) in Mainz, established as a member institute of the extra university Leibniz Association in January 2020, focuses on resilience research, meaning the ability to maintain or restore mental health during or after stressful life situations. The main goals of LIR are to understand resilience mechanisms from a neuroscientific perspective, to develop appropriate interventions to promote resilience and to work towards changing the living and working environment to finally strengthen resilience. To achieve this, neuroscientists, physicists, clinical scientists and psychologists work together in an interdisciplinary team. In currently 10 research groups, basic molecular research and human research are combined with genetic, epigenetic, metabolic, physiological, psychological and social science methods. Special competences exist in the fields of molecular biology, systems neuroscience, functional imaging, neurostimulation, as well as randomized controlled studies with patients, systematic reviews and meta-analyses. In addition, there are three research platforms (Mouse Behavioral Unit, MBU, Mainz Animal Imaging Centre, MAIC, and Clinical Investigation Centre, CIC) whose services are also available to cooperation partners.